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Regenerating Insulin-Producing Cells: A Potential Breakthrough for Type 1 Diabetes
The Brighter Side of News reports a breakthrough in diabetes research. Australian scientists at the Baker Heart and Diabetes Institute led by Professor Sam El-Osta demonstrated that pancreatic ductal progenitor cells can be reprogrammed to produce insulin after exposure to two FDA-approved EZH2 inhibitors, GSK126 and Tazemetostat. Within 48 hours, the cells began producing insulin and responding to glucose, effectively behaving like beta cells. The study uses cells from both diabetics and non-diabetics and shows that age or disease duration may not prevent regeneration. The findings, published in Nature, outline an epigenetic mechanism where blocking EZH2 alters histone marks and unleashes regenerative potential. Next steps involve preclinical testing and translating this approach to therapies that help people make their own insulin again. Author: The Brighter Side of News.