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Replenishing Brain Lithium May Protect Against and Reverse Alzheimer's, Nature Study Finds
Nature reports that a study examining human brain tissue and mouse models finds brain lithium declines accompany memory loss and Alzheimer’s disease hallmarks, including amyloid plaques and tau tangles. In mice, a brain lithium deficit accelerates pathology, while a low-dose lithium orotate supplement reverses brain damage and restores memory, unlike lithium carbonate. If validated in clinical trials, replenishing brain lithium could offer a broad, multi-pathology approach to dementia, complementing anti-amyloid therapies that slow decline but do not restore function. With dementia affecting more than 55 million people worldwide, this Nature-backed finding points to a potential new direction for treatment.